Anti-Rat C5b-9 Monoclonal Antibody (clone 2A1) -0.5 mg (CAT#: CB-P308-AB) Datasheet

Antibody

Monoclonal antibody 2A1 recognizes rat C5b-9. It shows that this antibody competes with human C9 antibody for its binding site in the C5b-9 complex, indicating that the reactive epitope is located on the C9 molecule. C5b-9 membrane attack is caused by serum The five precursor molecules in assemble the complex, C5 convertase proteolytically cleaves C5 to generate C5b, thereby initiating the assembly of the C5b-9 complex; the last step in the formation of the C5b-9 complex involves the polymerization of C9, accompanied by The complex is inserted during the polymerization reaction of C5b-8 and C9 to produce new antigens, which are unique to the C5b-9 complex and are not present in any single natural complex component. Complement regulatory protein CD59 and complement S protein can prevent C5b-9 from inserting into the cell membrane by both, and the formed SC5b-9 complex cannot attach to cells and has no cytolytic activity. Treat tuberous nephropathy by regulating continuous tubulointerstitial damage. Abolish C5b- After the 9 complex is formed, it can improve the early tubular interstitial damage of the remaining kidney.
Produce monoclonal antibody 2A1 against rat C5b-9 neoantigen. The monoclonal antibody 2A1 can be used as a coating antibody to detect C5b-9 in plasma and urine samples.

Infectious diseases, Nephrology