Anti-Platelet-derived growth factor C Antibody, Non-Fucosylated (BioBet-1564ZP) (CAT#: BioBet-1564ZP) Datasheet

PDGFC

PDGFC; platelet derived growth factor C; SCDGF; FALLOTEIN; platelet-derived growth factor C; PDGF-C; VEGF-E; spinal cord-derived growth factor; secretory growth factor-like protein;

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

platelet derived growth factor C

Plasma membrane, Extracellular region or secreted, Nucleus, Cytosol

Diseases associated with PDGFC include Milker's Nodule and Macular Degeneration, Age-Related, 1.

Its related pathways are Phospholipase D signaling pathway and Signaling by GPCR.

Growth factors that play an important role in embryonic development, cell proliferation, cell migration, survival and chemotaxis. A powerful chemotactic agent for cells of mitogen and mesenchymal origin. Necessary for normal bone formation during embryonic development, especially the normal development of the craniofacial skeleton and the normal development of the upper jaw. Required for normal skin morphology during embryonic development. It plays an important role in wound healing, and it seems to be involved in three stages: inflammation, proliferation and remodeling. It plays an important role in angiogenesis and blood vessel development. Participate in the process of fibrosis, in which mesenchymal fibroblasts transform into myofibroblasts and collagen deposition occurs. The CUB domain has mitotic activity in coronary artery smooth muscle cells, suggesting that its effect exceeds the incubation period for maintaining the PDGF domain. In the nucleus, PDGFC seems to have additional functions.

Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG. Sumoylated with SUMO1. N-glycosylated.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

16B1

Human

Human

The antibody bind to the PDGF-C antigen. Applications of such antibody include treatment of cancer.

Cancer

Cancer