Product Type
Antibody
Description
Porcine complement component C3 is recognized by polyclonal antibodies. The complement system is an important part of the humoral response in innate immunity and consists of three different pathways. The third complement component C3 is the classic complement of complement, replacement and the key complement of the lectin pathway. The activation product of the cascade reaction contains new epitopes, which are not present in various natural components. Complement factor C3 is composed of one α chain and one β chain.
The synthesis of C3 is tissue-specific and is regulated in response to a variety of stimulants. C3 is the most abundant protein in the complement system, and the serum protein level is about 1.3 mg/ml. Hereditary C3 deficiency makes people vulnerable to frequent attacks from bacterial infections. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported.
The proteolysis of certain enzymes causes the cleavage of C3 into C3a and C3b. C3b attaches to the immune complex and is further cleaved into iC3b, C3c, C3dg and C3f.
Disease
Pulmonology
Size
100 µg
Immunogen
Purified Pig C3
Species
Pig
Clonality
Polyclonal
Buffer
PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
Application
Flow cytometry
Application Notes
For flow cytometry, the use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution. The typical initial working dilution is 1:50. For functional studies, the in vitro dilution must be optimized in the user's experimental setting.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Alternative Names
Complement component C3
