Anti-NKG2D Antibody, Non-Fucosylated (BioBet-1156ZP) (CAT#: BioBet-1156ZP) Datasheet

KLRK1

killer cell lectin-like receptor subfamily K, member 1

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.

KLRK1; killer cell lectin-like receptor subfamily K, member 1; KLR; CD314; NKG2D; NKG2-D; D12S2489E; NKG2-D type II integral membrane protein; NK cell receptor D; NKG2-D-activating NK receptor

Plasma membrane

Diseases associated with KLRK1 include Cowpox and Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia.

Its related pathways are Immune response Role of DAP12 receptors in NK cells and Hematopoietic Stem Cells and Lineage-specific Markers.

As an activated and costimulatory receptor, it combines with various cell stress inducing ligands on the surface of autologous tumor cells and virus infected cells. It provides stimulation and co stimulation of innate immune response to activated killer cells (NK), resulting in cytotoxic activity. In the adaptive immune response mediated by CD8 (+) T cells, as a costimulatory receptor of T cell receptor (TCR), it can enhance the activation of T cells. It stimulates the elimination of tumor cells by stimulating perforin mediated ligand expression. Signal transduction includes calcium influx, which eventually leads to TNF - expression. It is involved in NK cell mediated rejection of bone marrow transplantation. It may regulate the differentiation and survival of NK cells. They bind to various subfamily ligands belonging to MHC class I related glycoproteins, including mica, MICB, raet1e, raet1g, raet1l / ulbp6, ulbp1, ulbp2, ULBP3 (ulbp2>, ulbp1> ULBP3) and ulbp4.

Immune System antibody

1.Glycosylation at Asn131, Asn163, and Asn202 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG4

16F31

Human

Human

The anti-human NKG2D monoclonal antibody with optimal properties for therapeutic use in inflammatory and autoimmune diseases and disorders.

Autoimmune Diseases; Inflammatory Diseases

Autoimmune Diseases; Inflammatory Diseases