Description
ADCC-Enhanced anti-NKG2D (MS) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Autoimmune Diseases; Inflammatory Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced NKG2D antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
KLRK1
Full Name
killer cell lectin-like receptor subfamily K, member 1
Background
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
Alternative Names
KLRK1; killer cell lectin-like receptor subfamily K, member 1; KLR; CD314; NKG2D; NKG2-D; D12S2489E; NKG2-D type II integral membrane protein; NK cell receptor D; NKG2-D-activating NK receptor
Gene ID
22914
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with KLRK1 include Cowpox and Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia.
Related Pathways
Its related pathways are Immune response Role of DAP12 receptors in NK cells and Hematopoietic Stem Cells and Lineage-specific Markers.
Function
As an activated and costimulatory receptor, it combines with various cell stress inducing ligands on the surface of autologous tumor cells and virus infected cells. It provides stimulation and co stimulation of innate immune response to activated killer cells (NK), resulting in cytotoxic activity. In the adaptive immune response mediated by CD8 (+) T cells, as a costimulatory receptor of T cell receptor (TCR), it can enhance the activation of T cells. It stimulates the elimination of tumor cells by stimulating perforin mediated ligand expression. Signal transduction includes calcium influx, which eventually leads to TNF - expression. It is involved in NK cell mediated rejection of bone marrow transplantation. It may regulate the differentiation and survival of NK cells. They bind to various subfamily ligands belonging to MHC class I related glycoproteins, including mica, MICB, raet1e, raet1g, raet1l / ulbp6, ulbp1, ulbp2, ULBP3 (ulbp2>, ulbp1> ULBP3) and ulbp4.
Field of research
Immune System antibody
Post-translational modifications
1.Glycosylation at Asn131, Asn163, and Asn202 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG4
Antibody Clone
MS
Description
The anti-human NKG2D monoclonal antibody with optimal properties for therapeutic use in inflammatory and autoimmune diseases and disorders.
Antibody Indication
Autoimmune Diseases; Inflammatory Diseases
Autoimmune Diseases; Inflammatory Diseases
