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Anti-Mouse Complement C5 Monoclonal Antibody (clone BB5.1) -10 mg (CAT#: CB-P530-K) Datasheet

Product Type
C5 is synthesized as a single polypeptide chain in the liver and is present in serum at a concentration of 50-80 μm/ml. Before secretion, the molecule is glycosylated and secreted into the plasma as a 190 kDa glycoprotein, which is composed of disulfide-linked α-chain (111 kDa) and β-chain (75 kDa). In functional complement tests, monoclonal antibody BB5.1 has been shown to precipitate two chains of C5 from normal mouse serum and inhibit C5-dependent hemolysis. In addition, during heart and kidney transplantation, BB5.1 administration completely inhibited the terminal complement activity of antibody-mediated rejection (AMR) in the murine model. In another mouse model, the pretreatment and intervention of monoclonal antibody BB5.1 both attenuate the disease development during glomerulonephritis induced by anti-MPO IgG. BB5.1 prevents C5 activation can prevent renal ischemia-reperfusion injury by inhibiting late-stage cell apoptosis and inflammation. In lupus disease, anti-IL-10/anti-C5 (BB5.1) combination therapy can both prevent and reduce the impact of humoral immune response.
100 µg
Cross reactivity

All products and services are for Research Use Only. Do Not use in humans.


Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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