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Creative Biolabs - ADCC+ Antibody

Anti-MASP-2 Antibody, Non-Fucosylated (BioBet-1820ZP) (CAT#: BioBet-1820ZP) Datasheet

Target
MASP-2
Isotype
IgG
Description
Anti-MASP-2 Antibody, Non-Fucosylated (BioBet-1820ZP) is a human monoclonal IgG antibody against MASP-2. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Hematopoietic stem cell transplant-associated thrombotic microangiopathies
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced MASP-2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MASP2
Full Name
mannan-binding lectin serine peptidase 2
Background
The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases.
Alternative Names
MASP2; mannan-binding lectin serine peptidase 2; sMAP; MAP19; MASP-2; MASP1P1; mannan-binding lectin serine protease 2; small MBL-associated protein; MBL-associated serine protease 2; MBL-associated plasma protein of 19 kD; mannan-binding lectin serine protease 1 pseudogene 1; mannose-binding protein-associated serine protease 2; mannan-binding lectin serine peptidase 1 pseudogene 1
Gene ID
10747
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1820ZP
Host
Human
Species Reactivity
Human
Description
This clone was generated using a stable CHO cell line with the FUT8 knockout gene. It was 100% non-fucosylated. In an in vitro cell-based ADCC assay, the afucosylated antibody clone showed significantly higher ADCC activity compared to its wild type version. The binding affinity of the non-fucosylated Fc variant antibody to Fc receptor is much higher than than the same antibody with fucosylated Fc. Robust and stable production of qualitative fully non-fucosylated therapeutic antibodies is achieved.
Antibody Indication
Hematopoietic stem cell transplant-associated thrombotic microangiopathies

Hematopoietic stem cell transplant-associated thrombotic microangiopathies

Related Products

Anti-MASP-2 Antibody, ADCC Enchanced (BioBet-CB-002LX) (CAT#: BioBet-CB-002LX)

All products and services are for Research Use Only. Do Not use in humans.

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