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Creative Biolabs - ADCC+ Antibody

Anti-MASP-2 Antibody, ADCC Enchanced (BioBet-CB-002LX) (CAT#: BioBet-CB-002LX) Datasheet

Target
MASP-2
Isotype
IgG4
Description
Anti-MASP-2 Antibody, ADCC Enchanced (BioBet-CB-002LX) is a glycosylation-modified anti-MASP-2 therapeutic antibody.
Antibody Indication
Chronic lymphocytic leukemia; follicular lymphoma; some types of non-Hodgkin lymphoma (NHL);some non-cancer related illnesses
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced MASP-2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MASP2
Full Name
mannan-binding lectin serine peptidase 2
Background
The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases.
Alternative Names
MASP2; mannan-binding lectin serine peptidase 2; sMAP; MAP19; MASP-2; MASP1P1; mannan-binding lectin serine protease 2; small MBL-associated protein; MBL-associated serine protease 2; MBL-associated plasma protein of 19 kD; mannan-binding lectin serine protease 1 pseudogene 1; mannose-binding protein-associated serine protease 2; mannan-binding lectin serine peptidase 1 pseudogene 1
Gene ID
10747
Field of research
Cell Biology, Immunology,
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG4
Antibody Clone
BioBet-CB-002LX
Host
Human
Species Reactivity
Human
Description
ADCC-Enhanced Anti-Human MASP-2 (Narsoplimab) Antibody is derived from clone Narsoplimab, which is a Human monoclonal antibody with enhanced ADCC activity. Antibody-dependent cellular cytotoxicity (ADCC) is an important function of antibody. It is a part of the humoral immune response to limit and contain infection. The antibody targets the MASP-2, and it is intended for the research of Hematopoietic stem cell transplant-associated thrombotic microangiopathies.
Antibody Indication
Hematopoietic stem cell transplant-associated thrombotic microangiopathies

Hematopoietic stem cell transplant-associated thrombotic microangiopathies

Related Products

Anti-MASP-2 Antibody, Non-Fucosylated (BioBet-1820ZP) (CAT#: BioBet-1820ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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