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Anti-IL-2R Antibody, Non-Fucosylated (BioBet-024ZP) (CAT#: BioBet-024ZP) Datasheet

Target
IL-2R
Isotype
IgG
Description
ADCC-enhanced Daclizumab is a non-fucosylated anti-IL-2R therapeutic biobetter antibody.
Antibody Indication
Relapsing Multiple Sclerosis (RMS)
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL-2R antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL-2R
Full Name
interleukin 2 receptor
Background
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Alternative Names
p55; CD25; IL2R; IMD41; TCGFR; IDDM10
Gene ID
3559
UniProt ID
P01589
Cellular Localization
Membrane;Single-pass type I membrane protein
Involvement in Disease
Diseases associated with IL2RA include Immunodeficiency 41 With Lymphoproliferation And Autoimmunity and Diabetes Mellitus, Insulin-Dependent, 10.
Related Pathways
Its related pathways are RET signaling and Signaling by GPCR.
Function
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Field of research
Immune System antibody; Pre-B Cell Marker antibody
Post-translational modifications
1.Glycosylation at Asn70, Asn89, Thr218, Thr224, Thr229, and Thr237 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
Daclizumab
Host
Human
Species Reactivity
Human
Description
Daclizumab is a therapeutic humanized monoclonal antibody for adults with relapsing multiple sclerosis (MS). Daclizumab works by binding to the alpha chain (CD25) of T cell IL-2 receptors.
Antibody Indication
Relapsing Multiple Sclerosis (RMS)

Relapsing Multiple Sclerosis (RMS)

Related Products

Anti-IL-2R Antibody, On-Target (AES-0622-ZP927) (CAT#: AES-0622-ZP927)
Anti-IL-2R Antibody, Highly Galactosylated (BioBet-GA-023ZP) (CAT#: BioBet-GA-023ZP)
Anti-IL-2R Antibody, Half-Life Extended (AES-0622-ZP1255) (CAT#: AES-0622-ZP1255)
Anti-IL-2R Antibody, FcγRIIB Binding Enhanced (AES-0622-ZP599) (CAT#: AES-0622-ZP599)
Anti-IL-2R Antibody, Non-Fucosylated (BioBet-023ZP) (CAT#: BioBet-023ZP)
Anti-IL-2R Antibody, Highly Galactosylated (BioBet-GA-024ZP) (CAT#: BioBet-GA-024ZP)
Anti-IL-2R Antibody, Recycling (AES-0622-ZP271) (CAT#: AES-0622-ZP271)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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