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Anti-IL-2R Antibody, Highly Galactosylated (BioBet-GA-023ZP) (CAT#: BioBet-GA-023ZP) Datasheet

Target
IL-2R
Isotype
IgG1
Description
Anti-IL-2R Antibody, Highly Galactosylated (BioBet-GA-023ZP) is a mouse IgG1 antibody against IL-2R which contains with a high level of galactosylation.
Antibody Indication
Kidney Transplant Rejection
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL-2R antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL-2R
Full Name
interleukin 2 receptor
Background
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Alternative Names
p55; CD25; IL2R; IMD41; TCGFR; IDDM10
Gene ID
3559
UniProt ID
P01589
Cellular Localization
Membrane;Single-pass type I membrane protein
Genecards
6008
Involvement in Disease
Its related pathways are RET signaling and Signaling by GPCR.
Related Pathways
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Function
Immune System antibody; Pre-B Cell Marker antibody
Field of research
1.Glycosylation at Asn70, Asn89, Thr218, Thr224, Thr229, and Thr237 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-GA-023ZP
Host
Mouse
Species Reactivity
Human
Description
Basiliximab is an immunosuppressant that targets the alpha chain (CD25) of T cell IL-2 receptors. It is used in combination with other drugs to prevent rejection in organ transplants, especially in kidney transplants.
Antibody Indication
Kidney Transplant Rejection

Kidney Transplant Rejection

Related Products

Anti-IL-2R Antibody, FcγRIIB Binding Enhanced (AES-0622-ZP599) (CAT#: AES-0622-ZP599)
Anti-IL-2R Antibody, Highly Galactosylated (BioBet-GA-024ZP) (CAT#: BioBet-GA-024ZP)
Anti-IL-2R Antibody, Non-Fucosylated (BioBet-024ZP) (CAT#: BioBet-024ZP)
Anti-IL-2R Antibody, Non-Fucosylated (BioBet-023ZP) (CAT#: BioBet-023ZP)
Anti-IL-2R Antibody, Recycling (AES-0622-ZP271) (CAT#: AES-0622-ZP271)
Anti-IL-2R Antibody, On-Target (AES-0622-ZP927) (CAT#: AES-0622-ZP927)
Anti-IL-2R Antibody, Half-Life Extended (AES-0622-ZP1255) (CAT#: AES-0622-ZP1255)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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