Anti-IFNα (alpha) [AIFN] Fc Silent Antibody, Human IgG1 lambda - Creative Biolabs
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Anti-IFNα (alpha) [AIFN] Fc Silent Antibody, Human IgG1 lambda (CAT#: BioBet-F687P) Datasheet

Product Type
Fc Silent Antibody
Description
The Fc-mediated effector functions of antibodies include antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC), and have been shown to be crucial for the therapeutic efficacy of most clinically approved antibodies. However, engaging immune effectors through FcγR and complement interactions may be detrimental to certain mAb mechanisms of action and so Fc-null or -silenced antibodies may be desired.

Creative Biolabs uses site-directed mutagenesis technology to generate Fc-silenced antibody with reduced effector functions. The mutated Fc domains eliminate the binding of Fc receptors (FcγR, FcR), thereby leading to a significant reduction in ADCC and CDC in comparison to WT IgG.
Immunogen
The scFv AIFNα1bScFv01 was generated by screening a non-immune synthetic human antibody phage display library. The scFv sequence isolated was then be fused to a human IgG1 constant region to create...
Species
Human
Cross reactivity
Human
Host
Human
Clonality
Monoclonal
Isotype
IgG1 lambda
Clone Number
AIFN
Conjugation
Unconjugated
Buffer
PBS only
Application
N
Storage Instructions
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Target
CD20

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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