Anti-Human Ficolin-2 Monoclonal Antibody (clone GN5) -0.5 mg (CAT#: CB-P365-AB) Datasheet

Antibody

The monoclonal antibody GN5 recognizes human Ficolin-2, also known as L-ficolin. Ficolins are a type of pattern recognition molecules that contain both collagen-like domains and fibrinogen-like domains, which can activate the complement system in humans by binding to People who have MASPs on the surface of microorganisms have three known Ficolins: Ficolin-1 (M-ficolin), Ficolin-2 (L-ficolin) and Ficolin-3 (H-ficolin). They are mainly composed of monocytes, granulocytes and lungs. The cells are expressed and locally present in the area of ​​inflammation.
Ficolin-2/P35 (also L-ficolin, Ficolin L, EBP-37 or hucolin) is mainly produced by the liver. The association between Ficolin-2/P35 and MASPs/sMAP is Ca2+ dependent. The MASP in the Ficolin-2/P35-MASP complex has proteolytic activity on C4, C2 and C3. Ficolin-2/P35 also shows opsonizing activity.

Cardiology and metabolism, Infectious diseases