Product Type
Antibody
Description
The monoclonal antibody GN5 recognizes human Ficolin-2, also known as L-ficolin. Ficolins are a type of pattern recognition molecules that contain both collagen-like domains and fibrinogen-like domains, which can activate the complement system in humans by binding to People who have MASPs on the surface of microorganisms have three known Ficolins: Ficolin-1 (M-ficolin), Ficolin-2 (L-ficolin) and Ficolin-3 (H-ficolin). They are mainly composed of monocytes, granulocytes and lungs. The cells are expressed and locally present in the area of inflammation.
Ficolin-2/P35 (also L-ficolin, Ficolin L, EBP-37 or hucolin) is mainly produced by the liver. The association between Ficolin-2/P35 and MASPs/sMAP is Ca2+ dependent. The MASP in the Ficolin-2/P35-MASP complex has proteolytic activity on C4, C2 and C3. Ficolin-2/P35 also shows opsonizing activity.
Disease
Cardiology and metabolism, Infectious diseases
Size
100 µg
Immunogen
Infectious diseases
Species
Human
Cross reactivity
Rat
Clonality
Monoclonal
Clone Number
GN5
Buffer
PBS, containing 0.02% sodium azide and 0.1% bovine Serum albumin.
Application
Frozen sections, Immuno assays, Immuno precipitation
Application Notes
The diluent used depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution. The typical initial working dilution is 1:50.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Alternative Names
Ficolin-2/P35; L-ficolin; ficolin L; EBP-37; hucolin; 37 kDa elastin-binding protein; Collagen/fibrinogen domain-containing protein 2; Ficolin-B; Ficolin-beta
