Product Type
Antibody
Description
The monoclonal antibody GN4 recognizes human Ficolin-2, also known as L-ficolin. Ficolins are a type of pattern recognition molecules that contain both collagen-like domains and fibrinogen-like domains, which can activate the complement system on the surface of microorganisms by binding to MASP. In humans, three types of Ficolins are known: Ficolin-1 (M-ficolin), Ficolin-2 (L-ficolin) and Ficolin-3 (H-ficolin). Ficolin-1 is mainly expressed by monocytes, granulocytes and lung cells, and is locally present in the inflammation area. Ficolin-2 (also called L-ficolin, Ficolin L, EBP-37 or hucolin) is mainly produced by the liver. The association between Ficolin-2 and MASP/sMAP is Ca2+ dependent. The MASP in the Ficolin-2-MASP complex has proteolytic activity on C4, C2 and C3. Ficolin-2 also shows opsonizing activity.
Disease
Cardiology and metabolism, Infectious diseases
Size
100 µg
Immunogen
Infectious diseases
Species
Human
Clonality
Monoclonal
Clone Number
GN4
Buffer
PBS, containing 0.02% sodium azide and 0.1% bovine Serum albumin.
Application
Frozen sections, Immuno assays, Immuno precipitation
Application Notes
The diluent used depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution. The typical initial working dilution is 1:50.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Alternative Names
Ficolin-2/P35; L-ficolin; ficolin L; EBP-37; hucolin; 37 kDa elastin-binding protein; Collagen/fibrinogen domain-containing protein 2; Ficolin-B; Ficolin-beta
