Anti-Human Complement Component C3d (C3d) Monoclonal Antibody (clone 3) -10 mg (CAT#: CB-P475-K) Datasheet

Antibody

Monoclonal antibody 3 (also called YB2/39-11-1-7) reacts with linear determinants in C3d. This "D" antigen is present on C3, C3b, iC3b, C3dg and C3d. The complement system is an important factor in innate immunity. The third complement component, C3, is essential to the classical, alternative and lectin pathways of complement activation. The activation products of the complement cascade contain new epitopes that are not present in various natural components. The synthesis of C3 is tissue-specific and is regulated in response to a variety of stimulants. C3 is the most abundant protein in the complement system, and the serum protein level is about 1.3 mg/ml. Inherited C3 deficiency makes people prone to bacterial infections. C3 fragments are deposited in tissues at the site of antibody-mediated immunopathology. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. The proteolysis of C3 convertase cleaves C3 into C3a and C3b. C3b attaches to the immune complex and is further cleaved into iC3b and C3f. iC3b is further processed into C3c and C3dg. C3dg can be cleaved into C3d and C3g, although this does not occur in plasma. Monoclonal antibody 3 recognizes C3, C3b, iC3b, C3dg and C3d. Monoclonal antibodies do not recognize C3c. In order to distinguish between C3 and C3b, an anti-C3a antibody (HM2074) must be used.