Product Type
Fc Silent Antibody
Description
Anti-Human CD40L-Fc silent antibody is derived from clone Letolizumab, which is a Human monoclonal antibody targeting the CD40L. And it is intended for the research of Autoimmune diseases, B cell malignancies.
Research Area
Cell Biology, Immunology
Antigen Distribution
Biased expression in bone marrow (RPKM 14.7), lymph node (RPKM 3.9) and 9 other tissues.
Disease
Autoimmune diseases, B cell malignancies
Size
100 ug
Immunogen
Recombinant Human CD40L protein
Species
Human
Clonality
Monoclonal
Clone Number
Letolizumab
Conjugation
Unconjugated
Source
Recombinant
Buffer
PBS, pH 7.4
Application
Funcs, In vivo assay
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Handling Advice
This product is for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Official Name
CD40 ligand
Full Name
CD40 ligand
Background
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.
Alternative Names
CD40L; IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L
Gene ID
959
Uniprot ID
P29965
