Anti-Human CD22 (SM03)-Fc silent antibody (CAT#: CB-LX207-A) Datasheet

100 ug

Human

Chimeric

Monoclonal

IgG1

SM03

Unconjugated

Recombinant

PBS, pH 7.4

The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.

This product is for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.

Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.

CD22

CD22

CD22 molecule

CD22 mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22