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Anti-CD22 Inotuzumab ozogamicin Antibody, a Fc Silent Biobetter (CAT#: FCS-113P) Datasheet

Product Type
Fc Silent Antibody
Description
The antibody Fc domain is responsible for the function in the antibody, while the Fab domain is responsible for targeting. Therefore, Fc engineering represents the engineering function of antibodies, which are effector functions, such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), and control the serum half-life. Therefore, Fc engineering for immune silencing or further protein engineering is essential for immune cell binding to antibodies.

The Fc-silenced antibody provided by Creative Biolabs contains key point mutations that eliminate the binding of Fc receptors (FcγR, FcR), thereby eliminating the cytotoxic (ADCC) effector function of the antibody.
Species
Human
Clonality
Monoclonal
Isotype
Human Therapeutic Antibody
Clone Number
Inotuzumab ozogamicin
Conjugation
Unconjugated
Source
Recombinant
Buffer
PBS, pH 7.4
Application
Funcs, In vivo assay
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Storage Instructions
Product should be stored at -20°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Target
CD22
Official Name
CD22
Full Name
CD22 Molecule
Background
CD22 (CD22 Molecule) is a Protein Coding gene.
Diseases associated with CD22 include Refractory Hematologic Cancer and Refractory Hairy Cell Leukemia.
Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System.
Gene Ontology (GO) annotations related to this gene include carbohydrate binding.
An important paralog of this gene is SIGLEC1.
Alternative Names
Epratuzumab; LymphoCide; 205923-57-5; AMG 412; hLL2; DB04958CD22; CD22 molecule; CD22 antigen; B-cell receptor CD22; sialic acid binding Ig like lectin 2; SIGLEC 2; SIGLEC2; BL-CAM; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule;
Gene ID
933
Uniprot ID
P20273

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All products and services are for Research Use Only. Do Not use in humans.

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