Book a Meeting

Anti-Ferroportin Antibody, Non-Fucosylated (BioBet-1758ZP) (CAT#: BioBet-1758ZP) Datasheet

Target
Ferroportin
Isotype
IgG
Description
Non-Fucosylated Anti-Human Ferroportin (C10G5) is a glycosylation-modified therapeutic biobetter antibody.
Antibody Indication
Anemia
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Ferroportin antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
SLC40A1
Full Name
solute carrier family 40 (iron-regulated transporter), member 1
Background
The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4).
Alternative Names
SLC40A1; solute carrier family 40 (iron-regulated transporter), member 1; FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3; solute carrier family 40 member 1; iron regulated gene 1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
Gene ID
30061
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
C10G5
Host
Chimeric
Species Reactivity
Human
Description
This clone was generated using a stable CHO cell line with the FUT8 knockout gene. It was 100% non-fucosylated. In an in vitro cell-based ADCC assay, the afucosylated antibody clone showed significantly higher ADCC activity compared to its wild type version. The binding affinity of the non-fucosylated Fc variant antibody to Fc receptor is much higher than than the same antibody with fucosylated Fc. Robust and stable production of qualitative fully non-fucosylated therapeutic antibodies is achieved.
Antibody Indication
Anemia

Related Products

Anti-Ferroportin Antibody, Non-Fucosylated (BioBet-1757ZP) (CAT#: BioBet-1757ZP)
Anti-Ferroportin Antibody, Non-Fucosylated (BioBet-1297ZP) (CAT#: BioBet-1297ZP)
Anti-Ferroportin Antibody, Non-Fucosylated (BioBet-1756ZP) (CAT#: BioBet-1756ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.