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Anti-Ferroportin Antibody, Non-Fucosylated (BioBet-1297ZP) (CAT#: BioBet-1297ZP) Datasheet

Target
Ferroportin
Isotype
IgG4
Description
Anti-Ferroportin Antibody, Non-Fucosylated (BioBet-1297ZP) is a humanized monoclonal IgG4 antibody against Ferroportin. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Anemia
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Ferroportin antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
SLC40A1
Full Name
solute carrier family 40 (iron-regulated transporter), member 1
Background
The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4).
Alternative Names
SLC40A1; solute carrier family 40 (iron-regulated transporter), member 1; FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3; solute carrier family 40 member 1; iron regulated gene 1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
Gene ID
30061
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with SLC40A1 include Hemochromatosis, Type 4 and Hemochromatosis, Type 1.
Related Pathways
Its related pathways are Mineral absorption and Insulin receptor recycling.
Function
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).
Post-translational modifications
1.Glycosylation at Asn174, Asn434, and Asn567 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG4
Antibody Clone
BioBet-1297ZP
Host
Humanized
Species Reactivity
Human
Description
LY2928057 is a novel humanized IgG4 monoclonal antibody that binds to human ferroportin with a high affinity, blocks the binding of human hepcidin to ferroportin, and is a potent inhibitor of hepcidin activity in a recombinant ferroportin expressing HEK 293 cell-based assay. LY2928057 may provide therapeutic benefit for patients with hepcidin-related anemia by stabilizing ferroportin located on the cell surface, thus restoring iron export and erythropoiesis. LY2928057 is currently in clinical evaluation.
Antibody Indication
Anemia

Anemia

Related Products

Anti-Ferroportin Antibody, Non-Fucosylated (BioBet-1758ZP) (CAT#: BioBet-1758ZP)
Anti-Ferroportin Antibody, Non-Fucosylated (BioBet-1757ZP) (CAT#: BioBet-1757ZP)
Anti-Ferroportin Antibody, Non-Fucosylated (BioBet-1756ZP) (CAT#: BioBet-1756ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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