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Anti-CRTh2 Antibody, Non-Fucosylated (BioBet-1742ZP) (CAT#: BioBet-1742ZP) Datasheet

Target
CRTh2
Isotype
IgG
Description
Non-Fucosylated Anti-Human CRTh2 (8B1) is a glycosylation-modified therapeutic biobetter antibody.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CRTh2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
PTGDR2
Full Name
prostaglandin D2 receptor 2
Background
This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2014]
Alternative Names
PTGDR2; prostaglandin D2 receptor 2; DP2; DL1R; CD294; CRTH2; GPR44; G protein-coupled receptor 44; G-protein coupled receptor 44; putative G-protein coupled receptor 44; chemoattractant receptor-homologous molecule expressed on TH2 cells; chemoattractant receptor homologous molecule expressed on T helper type 2 cells;
Gene ID
11251
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
8B1
Host
Murine
Species Reactivity
Human
Description
This clone was generated using a stable CHO cell line with the FUT8 knockout gene. It was 100% non-fucosylated. In an in vitro cell-based ADCC assay, the afucosylated antibody clone showed significantly higher ADCC activity compared to its wild type version. The binding affinity of the non-fucosylated Fc variant antibody to Fc receptor is much higher than than the same antibody with fucosylated Fc. Robust and stable production of qualitative fully non-fucosylated therapeutic antibodies is achieved.
Antibody Indication
Cancer

Related Products

Anti-CRTh2 Antibody, Non-Fucosylated (BioBet-1741ZP) (CAT#: BioBet-1741ZP)
Anti-CRTh2 Antibody, Non-Fucosylated (19A2.v52) (CAT#: BioBet-1555ZP)
Anti-CRTh2 Antibody, Non-Fucosylated (BioBet-1745ZP) (CAT#: BioBet-1745ZP)
Anti-CRTh2 Antibody, Non-Fucosylated (BioBet-1743ZP) (CAT#: BioBet-1743ZP)
Anti-CRTh2 Antibody, Non-Fucosylated (19A2.v46) (CAT#: BioBet-1556ZP)
Anti-CRTh2 Antibody, Non-Fucosylated (BioBet-1744ZP) (CAT#: BioBet-1744ZP)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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