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Anti-CRTh2 Antibody, Non-Fucosylated (19A2.v46) (CAT#: BioBet-1556ZP) Datasheet

Target
CRTh2
Isotype
IgG1
Description
ADCC-Enhanced anti-CRTh2 (19A2.v46) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CRTh2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
PTGDR2
Full Name
prostaglandin D2 receptor 2
Background
This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2014]
Alternative Names
PTGDR2; prostaglandin D2 receptor 2; DP2; DL1R; CD294; CRTH2; GPR44; G protein-coupled receptor 44; G-protein coupled receptor 44; putative G-protein coupled receptor 44; chemoattractant receptor-homologous molecule expressed on TH2 cells; chemoattractant receptor homologous molecule expressed on T helper type 2 cells;
Gene ID
11251
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with PTGDR2 include Eosinophilic Pustular Folliculitis and Folliculitis.
Related Pathways
Its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR.
Function
Prostaglandin D2 receptor (PGD2). Linked to G(i) protein. Receptor activation may cause pertussis toxin-sensitive cAMP levels to decrease and Ca(2+) mobilization. The PI3K signaling pathway is also involved in mediating the PTGDR2 effect. PGD2 induces receptor internalization. CRTH2 internalization can be regulated by PKC, PKA, GRK2, GPRK5/GRK5, GRK6 and other kinases. Receptor activation is at least partly involved in immune regulation and allergic/inflammatory response.
Post-translational modifications
1.Phosphorylated 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn4 and Asn25
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
19A2.v46
Host
Humanized
Species Reactivity
Human
Description
The anti-CRTh2 antibody is involved decreasing the rate of disease progression, ameliorating or palliating the disease state, and remission or improved prognosis for tumor in mammals.
Antibody Indication
Cancer

Cancer

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All products and services are for Research Use Only. Do Not use in humans.

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