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Creative Biolabs - ADCC+ Antibody

Anti-CD5 Antibody, Non-Fucosylated (BioBet-155ZP) (CAT#: BioBet-155ZP) Datasheet

Target
CD5
Isotype
IgG
Description
Anti-CD5 Antibody, Non-Fucosylated (BioBet-155ZP) is a mouse monoclonal IgG antibody against CD5. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Graft-versus-host disease (GvHD)
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD5 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD5
Full Name
CD5 Molecule
Background
CD5 (CD5 Molecule) is a Protein Coding gene.
Diseases associated with CD5 include Thymus Cancer and Richter's Syndrome.
Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and B Cell Development Pathways.
Gene Ontology (GO) annotations related to this gene include receptor activity and scavenger receptor activity.
Alternative Names
Zolimomab aritox;141483-72-9;H65-RTA;XomaZyme-H65;CD5;CD5 molecule;CD5 antigen (p56 62) , LEU1;T-cell surface glycoprotein CD5;T1;CD5 antigen (p56-62);lymphocyte antigen T1/Leu-1;LEU1;
Gene ID
921
UniProt ID
P06127
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CD5 include Richter's Syndrome and Thymic Carcinoma.
Related Pathways
Its related pathways are Hematopoietic cell lineage and Hematopoietic Stem Cells and Lineage-specific Markers.
Function
May act as a receptor in regulating T-cell proliferation.
Post-translational modifications
Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-155ZP
Host
Mouse
Species Reactivity
Human
Description
Recombinant mouse monoclonal antibody scFv fragment expressed in E. Coli binding to human CD5. Zolimomab aritox is a mouse monoclonal antibody which has been investigated for the treatment of systemic lupus erythematosus and graft-versus-host disease, but the studies failed to show positive effects of the drug.It is an anti-CD5 antibody which is linked to the A chain of the ricin protein.
Antibody Indication
Graft-versus-host disease (GvHD)

Graft-versus-host disease (GvHD)

Related Products

Anti-CD5 Antibody, Non-Fucosylated (BioBet-156ZP) (CAT#: BioBet-156ZP)
Anti-CD5 Antibody, FcγRIIB Binding Enhanced (AES-0622-ZP584) (CAT#: AES-0622-ZP584)
Anti-CD5 Antibody, Recycling (AES-0622-ZP256) (CAT#: AES-0622-ZP256)
Anti-CD5 Antibody, Highly Galactosylated (BioBet-GA-155ZP) (CAT#: BioBet-GA-155ZP)
Anti-CD5 Antibody, Half-Life Extended (AES-0622-ZP1240) (CAT#: AES-0622-ZP1240)
Anti-CD5 Antibody, Highly Galactosylated (BioBet-GA-156ZP) (CAT#: BioBet-GA-156ZP)
Anti-CD5 Antibody, On-Target (AES-0622-ZP912) (CAT#: AES-0622-ZP912)

All products and services are for Research Use Only. Do Not use in humans.

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