Anti-CD45 Antibody, Non-Fucosylated (sc713) (CAT#: BioBet-1521ZP) Datasheet

PTPRC

protein tyrosine phosphatase, receptor type, C

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

PTPRC; protein tyrosine phosphatase, receptor type, C; LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; receptor-type tyrosine-protein phosphatase C; CD45 antigen; T200 glycoprotein; T200 leukocyte common antigen; protein tyrosine phosphatase, receptor type, c polypeptide;

Plasma membrane

Diseases associated with PTPRC include Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive and Hepatitis C Virus.

Its related pathways are B cell receptor signaling pathway (KEGG) and Activation of cAMP-Dependent PKA.

Activate the protein tyrosine-protein phosphatase required by T cells through antigen receptors. As a positive regulator of the cooperative activation of t cells and DPP4. The first PTPase domain has enzymatic activity, while the second domain seems to affect the substrate specificity of the first domain. Upon T cell activation, SKAP1 and FYN are recruited and dephosphorylated. Dephosphorylate LYN, thereby modulating LYN activity (through similarity). (Microbial infection) As a receptor for the human cytomegalovirus protein UL11, it mediates the binding of UL11 to t cells, resulting in the weakening of the induction of tyrosine phosphorylation of a variety of signal proteins when the t cell receptor is stimulated, and the damage of t cell proliferation.

Developmental Biology antibody; Immune System antibody; Neuroscience antibody; Signaling Transduction antibody; Mouse Inflammatory Cell Marker antibody; B Cell Marker antibody

Heavily N- and O-glycosylated.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

sc713

Human

Human

The antibody specifically recognize the human CD45 isoform RB, and may be used to block undesirable immune reactions in patients with transplant rejection and autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and autoimmune diabetes.

Rheumatoid Arthritis; Multiple Sclerosis; Autoimmune diabetes

Rheumatoid Arthritis; Multiple Sclerosis; Autoimmune diabetes