Description
Anti-CD4 Antibody, Non-Fucosylated (BioBet-138ZP) is a human monoclonal IgG1, κ antibody against CD4. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cutaneous T cell lymphoma (CTCL)
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD4 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Background
CD4 (CD4 Molecule) is a Protein Coding gene.
Diseases associated with CD4 include Okt4 Epitope Deficiency and Pilonidal Sinus.
Among its related pathways are G-protein signaling N-RAS regulation pathway and PEDF Induced Signaling.
Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding.
Alternative Names
Zanolimumab; humax-cd4; 652153-01-0; 6G5.2; HuMax-CD4; CD4; CD4 molecule; CD4 antigen (p55), T cell surface glycoprotein CD4; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD4mut;
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CD4 include Okt4 Epitope Deficiency and Human Immunodeficiency Virus Infectious Disease.
Related Pathways
Its related pathways are Clathrin-mediated endocytosis and TCR Signaling (Qiagen).
Function
Integral membrane glycoproteins play an important role in the immune response and perform multiple functions in fighting external and internal attacks. In T cells, it is mainly used as a co-receptor for MHC class II molecules: peptide complexes. Class II peptide antigens are derived from extracellular proteins, while class I peptides are derived from cytoplasmic proteins. It also interacts with MHC II presented by T cell receptors (TCR) and antigen presenting cells (APCs). Then, the Src kinase LCK was called to the vicinity of the TCR-CD3 complex. Then, LCK activates different intracellular signaling pathways through phosphorylation of various substrates, which ultimately leads to the production, activity, adhesion, and activation of T helper cells. In other cells such as macrophages or NK cells, they participate in differentiation/activation, cytokine expression and cell migration through a TCR/lck-independent pathway. Participate in the development of thymic t helper cells, triggering monocytes to differentiate into functional mature macrophages. 2.
Field of research
Developmental Biology antibody; Immune System antibody; Regulatory T cells Study antibody; T-cell infiltration Study antibody; Tumor-infiltrating Lymphocyte Study antibody
Post-translational modifications
Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-138ZP
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD4. Zanolimumab (expected trade name HuMax-CD4) is a human monoclonal antibody and an immunosuppressive drug. It is being developed for the treatment of rheumatoid arthritis, psoriasis, melanoma, cutaneous and peripheral T-cell lymphoma.
Antibody Indication
Cutaneous T cell lymphoma (CTCL)
