Description
ADCC-Enhanced anti-CD3 (AFM15) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Autoimmune Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD3 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD3
Full Name
CD3 T-Cell Co-receptor
Background
In immunology, the CD3 (cluster of differentiation 3) T-cell co-receptor is a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with a molecule known as the T-cell receptor (TCR) and the ζ-chain to generate an activation signal in T lymphocytes. The TCR, ζ-chain, and CD3 molecules together comprise the TCR complex.
Alternative Names
CD3; CD3 T-Cell Co-receptor;CD3D; CD3E; CD3G
UniProt ID
Q5ZPR3
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CD3E include Immunodeficiency 18 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta.
Related Pathways
Its related pathways are Nur77 Signaling in T-Cell and NF-KappaB Family Pathway.
Function
Part of the TCR-CD3 complex exists on the surface of t lymphocytes and plays an important role in the adaptive immune response. When antigen-presenting cells (APCs) activate T cell receptors (TCR), TCR-mediated signals are transmitted through the cell membrane through the CD3 chain CD3D, CD3E, CD3G, and CD3Z. The cytoplasmic domains of all CD3 chains contain tyrosine-based immune receptor activation motifs (ITAMs). When TCR is involved, these motifs are phosphorylated by Src family protein tyrosine kinases LCK and FYN, leading to the activation of downstream signaling pathways. In addition to the role of signal transduction in the activation of T cells, CD3E also plays an important role in the correct development of T cells. The assembly of TCR-CD3 complex is initiated by forming two heterodimers, CD3D/CD3E and CD3G/CD3E. The endocytic sequence that exists through the cytoplasmic region of CD3E participates in the internalization of the TCR-CD3 complex and the downregulation of the cell surface.
Field of research
Cancer antibody; Developmental Biology antibody; Immune System antibody; Lymphocyte Marker antibody; Inflammatory Cell Marker antibody; T-cell Marker antibody; T-cell infiltration Study antibody; Tumor-infiltrating Lymphocyte Study antibody
Post-translational modifications
1.Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. 2.Modification sites at PhosphoSitePlus 3.Ubiquitination at Lys104 and Lys177
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
AFM15
Description
AFM15 is an anti-CD3 antibody for the treatment of T-cell-mediated autoimmune diseases.
Antibody Indication
Autoimmune Diseases
