Anti-CD3 Antibody, Non-Fucosylated (BioBet-132ZP) (CAT#: BioBet-132ZP) Datasheet

CD3D

CD3d Molecule

CD3D (CD3d Molecule) is a Protein Coding gene.
Diseases associated with CD3D include Immunodeficiency 19 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta.
Among its related pathways are G-protein signaling N-RAS regulation pathway and Toll-like receptor signaling pathway.
Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity.
An important paralog of this gene is CD3G.

Teplizumab;876387-05-2;MGA031;hOKT3gamma1(Ala-Ala);CD3D;CD3d molecule, delta (CD3-TCR complex);CD3d antigen, delta polypeptide (TiT3 complex) , T3D;T-cell surface glycoprotein CD3 delta chain;CD3 delta;OKT3, delta chain;CD3 antigen, delta subunit;T-cell r

Plasma membrane

Diseases associated with CD3D include Immunodeficiency 19 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta.

Its related pathways are Nur77 Signaling in T-Cell and Clathrin-mediated endocytosis.

Part of the TCR-CD3 complex exists on the surface of t lymphocytes and plays an important role in the adaptive immune response. When antigen-presenting cells (APCs) activate T cell receptors (TCR), TCR-mediated signals are transmitted through the cell membrane through the CD3 chain CD3D, CD3E, CD3G, and CD3Z. The cytoplasmic domains of all CD3 chains contain tyrosine-based immune receptor activation motifs (ITAMs). When TCR is involved, these motifs are phosphorylated by Src family protein tyrosine kinases LCK and FYN, leading to the activation of downstream signaling pathways (PubMed: 2470098). In addition to the signal transduction role of T cell activation, CD3D also plays an important role in the differentiation of thymocytes. Indeed, it is involved in the correct assembly and surface expression of the TCR-CD3 complex in the cell. If there is no functional TCR-CD3 complex, thymocytes cannot differentiate normally. It interacts with CD4 and CD8 to establish a functional link between TCR and the co-receptors CD4 and CD8, which is necessary for CD4 or CD8 t cell activation and positive selection (PubMed:12215456).

Cancer antibody; Developmental Biology antibody; Immune System antibody; Lymphocyte Marker antibody; Inflammatory Cell Marker antibody; T-cell Marker antibody; T-cell infiltration Study antibody; Tumor-infiltrating Lymphocyte Study antibody

1.Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8 2.Glycosylation at Asn38 and Asn74 3.Ubiquitination at Lys80 and Lys82 4.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1, κ

BioBet-132ZP

Humanized

Human

Recombinant monoclonal antibody to CD3. Teplizumab is a monoclonal antibody which is used as an immunosuppressive drug. Teplizumab is a humanized Fc-engineered monoclonal antibody also known as MGA031 and hOKT3γ1(Ala-Ala).

Type 1 diabetes

Type 1 diabetes