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Anti-CD27 Antibody, Non-Fucosylated (BioBet-652ZP) (CAT#: BioBet-652ZP) Datasheet

Target
CD27
Isotype
IgG
Description
ADCC-Enhanced anti-CD27 is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Autoimmune Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD27 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD27
Full Name
CD27 molecule
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Alternative Names
CD27; CD27 molecule; T14; S152; Tp55; TNFRSF7; S152. LPFS2; CD27 antigen; CD27L receptor; T cell activation antigen S152; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily, member 7
Gene ID
939
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with CD27 include Lymphoproliferative Syndrome 2 and Combined T Cell And B Cell Immunodeficiency.
Related Pathways
Its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and Akt Signaling.
Function
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Field of research
Cancer antibody; Developmental Biology antibody; Immune System antibody
Post-translational modifications
Phosphorylated. O-glycosylated with core 1 or possibly core 8 glycans.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-652ZP
Host
Human
Species Reactivity
Human
Description
Human antibody immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27. The antibody are useful in diagnosing or treating CD27 activity associated diseases and conditions.
Antibody Indication
Autoimmune Diseases

Autoimmune Diseases

Related Products

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Anti-CD27 Antibody, Recycling (AES-0622-ZP248) (CAT#: AES-0622-ZP248)
Anti-CD27 Antibody, Highly Galactosylated (BioBet-GA-117ZP) (CAT#: BioBet-GA-117ZP)
Anti-CD27 Antibody, Half-Life Extended (AES-0622-ZP1232) (CAT#: AES-0622-ZP1232)
Anti-CD27 Antibody, FcγRIIB Binding Enhanced (AES-0622-ZP576) (CAT#: AES-0622-ZP576)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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