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Anti-CD27 Antibody, Non-Fucosylated (BioBet-117ZP) (CAT#: BioBet-117ZP) Datasheet

Target
CD27
Isotype
IgG1, κ
Description
Anti-CD27 Antibody, Non-Fucosylated (BioBet-117ZP) is a human monoclonal IgG1, κ antibody against CD27. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Solid tumors
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD27 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD27
Full Name
CD27 Molecule
Background
CD27 (CD27 Molecule) is a Protein Coding gene.
Diseases associated with CD27 include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Disease.
Among its related pathways are Cytokine Signaling in Immune system and Akt Signaling.
Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process.
Alternative Names
Varlilumab; CD27; CD27 molecule; TNFRSF7, tumor necrosis factor receptor superfamily, member 7; CD27 antigen; S152; Tp55; CD27L receptor; T cell activation antigen S152; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily, member 7; T14;
Gene ID
939
UniProt ID
P26842
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with CD27 include Lymphoproliferative Syndrome 2 and Combined T Cell And B Cell Immunodeficiency.
Related Pathways
Its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and Akt Signaling.
Function
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Post-translational modifications
1.Phosphorylated. 2.O-glycosylated with core 1 or possibly core 8 glycans.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, κ
Antibody Clone
BioBet-117ZP
Host
Human
Species Reactivity
Human
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human antibody to Human CD27. Varlilumab is an immunotherapy designed to enhance the body's natural immune response by directly activating T cells that can specifically recognize and kill cancer cells.
Antibody Indication
Solid tumors

Solid tumors

Related Products

Anti-CD27 Antibody, Recycling (AES-0622-ZP248) (CAT#: AES-0622-ZP248)
Anti-CD27 Antibody, FcγRIIB Binding Enhanced (AES-0622-ZP576) (CAT#: AES-0622-ZP576)
Anti-CD27 Antibody, On-Target (AES-0622-ZP904) (CAT#: AES-0622-ZP904)
Anti-CD27 Antibody, Half-Life Extended (AES-0622-ZP1232) (CAT#: AES-0622-ZP1232)
Anti-CD27 Antibody, Highly Galactosylated (BioBet-GA-117ZP) (CAT#: BioBet-GA-117ZP)
Anti-CD27 Antibody, Non-Fucosylated (BioBet-652ZP) (CAT#: BioBet-652ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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