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Anti-CD252 Antibody, Non-Fucosylated (BioBet-481ZP) (CAT#: BioBet-481ZP) Datasheet

Target
CD252
Isotype
IgG4, κ
Description
Anti-CD252 Antibody, Non-Fucosylated (BioBet-481ZP) is a human monoclonal IgG4, κ antibody against CD252. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Asthma
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD252 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TNFSF4
Full Name
TNFSF4 Gene(Protein Coding)


TNF Superfamily Member 4
Background
This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Alternative Names
Oxelumab;1186098-83-8;RO4989991;RG4930;huMAb OX40L;TNFSF4;tumor necrosis factor (ligand) superfamily, member 4;tax transcriptionally activated glycoprotein 1, 34kD , TXGP1;tumor necrosis factor ligand superfamily member 4;CD252;gp34;OX 40L;OX40L;CD134 lig
Gene ID
7292
UniProt ID
P23510
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with TNFSF4 include Myocardial Infarction and Systemic Lupus Erythematosus.
Related Pathways
Its related pathways are PEDF Induced Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.
Function
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
Post-translational modifications
1.Glycosylation at Asn90, Asn114, Asn152, and Asn157 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG4, κ
Antibody Clone
BioBet-481ZP
Host
Human
Species Reactivity
Human
Description
ADCC-enhanced Oxelumab is a non-fucosylated anti-CD252 therapeutic biobetter antibody.
Antibody Indication
Asthma

Asthma

Related Products

Anti-CD252 Antibody, Recycling (AES-0622-ZP328) (CAT#: AES-0622-ZP328)
Anti-CD252 Antibody, FcγRIIB Binding Enhanced (AES-0622-ZP656) (CAT#: AES-0622-ZP656)
Anti-CD252 Antibody, Half-Life Extended (AES-0622-ZP1312) (CAT#: AES-0622-ZP1312)
Anti-CD252 Antibody, On-Target (AES-0622-ZP984) (CAT#: AES-0622-ZP984)
Anti-CD252 Antibody, Highly Galactosylated (BioBet-GA-481ZP) (CAT#: BioBet-GA-481ZP)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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