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Creative Biolabs - ADCC+ Antibody

Anti-CD25 Antibody, Non-Fucosylated (BioBet-303ZP) (CAT#: BioBet-303ZP) Datasheet

Target
CD25
Isotype
IgG
Description
Anti-CD25 Antibody, Non-Fucosylated (BioBet-303ZP) is a human monoclonal IgG antibody against CD25. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD25 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL2RA
Full Name
Interleukin 2 Receptor Subunit Alpha
Background
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
Alternative Names
IL2RA; interleukin 2 receptor; alpha; p55; CD25; IL2R; TCGFR; IDDM10; interleukin-2 receptor subunit alpha; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha; HuMax-TAC
Gene ID
3559
UniProt ID
P01589
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with IL2RA include Immunodeficiency 41 With Lymphoproliferation And Autoimmunity and Diabetes Mellitus, Insulin-Dependent, 10.
Related Pathways
Its related pathways are RET signaling and Signaling by GPCR.
Function
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Field of research
Immune System antibody; Pre-B Cell Marker antibody
Post-translational modifications
1.Glycosylation at Asn70, Asn89, Thr218, Thr224, Thr229, and Thr237 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-303ZP
Host
Human
Species Reactivity
Human
Description
Anti-CD25 antibody is a Human antibody of IgG class that binds to an CD25.

Related Products

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Anti-CD25 Antibody, Non-Fucosylated (BioBet-304ZP) (CAT#: BioBet-304ZP)
Anti-CD25 Antibody, Highly Galactosylated (BioBet-GA-305ZP) (CAT#: BioBet-GA-305ZP)
Anti-CD25 Antibody, Highly Galactosylated (BioBet-GA-303ZP) (CAT#: BioBet-GA-303ZP)
Anti-CD25 Antibody, Half-Life Extended (AES-0622-ZP1016) (CAT#: AES-0622-ZP1016)
Anti-CD25 Antibody, Highly Galactosylated (BioBet-GA-304ZP) (CAT#: BioBet-GA-304ZP)
Anti-CD25 Antibody, FcγRIIB Binding Enhanced (AES-0622-ZP360) (CAT#: AES-0622-ZP360)

All products and services are for Research Use Only. Do Not use in humans.

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