Description
Anti-CD22 Antibody, Highly Galactosylated (BioBet-GA-111ZP) is a humanized IgG4, κ antibody against CD22 which contains with a high level of galactosylation.
Antibody Indication
B cell lymphoma
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD22 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD22
Full Name
CD22 Molecule
Background
CD22 (CD22 Molecule) is a Protein Coding gene.
Diseases associated with CD22 include Refractory Hematologic Cancer and Refractory Hairy Cell Leukemia.
Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System.
Gene Ontology (GO) annotations related to this gene include carbohydrate binding.
An important paralog of this gene is SIGLEC1.
Alternative Names
Epratuzumab; LymphoCide; 205923-57-5; AMG 412; hLL2; DB04958CD22; CD22 molecule; CD22 antigen; B-cell receptor CD22; sialic acid binding Ig like lectin 2; SIGLEC 2; SIGLEC2; BL-CAM; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule;
Gene ID
933
UniProt ID
P20273
Cellular Localization
Plasma membrane
Genecards
1643
Involvement in Disease
Its related pathways are B cell receptor signaling pathway (KEGG) and Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
Related Pathways
Mediates the interaction between b cells and b cells. It may be involved in the localization of b cells in lymphoid tissues. Binds sialylated glycoproteins; one of them is CD45. It preferentially binds to -2,6-linked sialic acid. The sialic acid recognition site can be masked by the cis interaction with sialic acid on the same cell surface. Tyrosine phosphorylation appears to be involved in the regulation of b-cell antigen receptor signaling in the ligand-induced immune response. It plays a positive regulatory role through the interaction with Src family tyrosine kinases, and may also act as an inhibitory receptor by recruiting the SH2 domain of cytoplasmic phosphatase and blocking signal transduction through dephosphorylation of signal molecules.
Function
Cancer antibody; Developmental Biology antibody; Immune System antibody; Immature B Cell Marker antibody
Field of research
Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2. Phosphorylated on tyrosine residues by LYN.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG4, κ
Antibody Clone
BioBet-GA-111ZP
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD22.
Antibody Indication
B cell lymphoma
