Description
Anti-CD2 Antibody, Highly Galactosylated (BioBet-GA-108ZP) is a humanized IgG1, κ antibody against CD2 which contains with a high level of galactosylation.
Antibody Indication
Psoriasis
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD2
Full Name
CD2 Molecule
Background
CD2 (CD2 Molecule) is a Protein Coding gene.
Diseases associated with CD2 include Penis Squamous Cell Carcinoma and Immune Defect Due To Absence Of Thymus.
Among its related pathways are PEDF Induced Signaling and Akt Signaling.
Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and receptor activity.
Alternative Names
Siplizumab; 288392-69-8; MEDI-507; CD2; CD2 molecule; CD2 antigen (p50), sheep red blood cell receptor, SRBC; T-cell surface antigen CD2; LFA-3 receptor; rosette receptor; erythrocyte receptor; lymphocyte-function antigen-2; T-cell surface antigen T11/Leu-5;
Gene ID
914
UniProt ID
P06729
Cellular Localization
Plasma membrane
Genecards
1639
Involvement in Disease
Its related pathways are Cell surface interactions at the vascular wall and PEDF Induced Signaling.
Related Pathways
CD2 interacts with lymphocyte function-related antigens CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is involved in the triggering of t cells, and the cytoplasmic domain is involved in signal transduction.
Field of research
1.Glycosylation at Asn89, Asn141, and Asn150 2.Ubiquitination at Lys264 and Lys310 3.Modification sites at PhosphoSitePlus 4.Glycosylation from GlyConnect
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, κ
Antibody Clone
BioBet-GA-108ZP
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD2. Siplizumab (MEDI-507) is a novel monoclonal antibody with a human IgG1, kappa directed to CD2. The agent has shown potent immunomodulatory effects, selectively suppressing the function of T and NK cells, and is currently being tested as a possible treatment for psoriasis and in the prevention of graft-versus-host disease.
Antibody Indication
Psoriasis
