Description
Anti-CD15/FUT4 Antibody, Non-Fucosylated (BioBet-240ZP) is a mouse monoclonal IgG antibody against CD15/FUT4. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Appendicitis (Radionuclide imaging)
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD15/FUT4 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
FUT4
Full Name
Fucosyltransferase 4
Background
The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]
Alternative Names
technetium (99mTc) fanolesomab;neutrospec;225239-31-6;FUT4;fucosyltransferase 4 (alpha (1, 3) fucosyltransferase, myeloid-specific);CD15, ELFT, FCT3A;alpha-(1, 3)-fucosyltransferase;ELAM ligand fucosyltransferase;FUC TIV;galactoside 3 L fucosyltransferase
Gene ID
2526
UniProt ID
P22083
Cellular Localization
Golgi apparatus
Involvement in Disease
Diseases associated with FUT4 include Hodgkin's Lymphoma, Mixed Cellularity and Hodgkin's Lymphoma, Lymphocytic-Histiocytic Predominance.
Related Pathways
Its related pathways are Glycosphingolipid biosynthesis - lacto and neolacto series and Metabolism.
Function
May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.
Post-translational modifications
1.Glycosylation at Asn216 and Asn315 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-240ZP
Description
Recombinant mouse monoclonal antibody expressed in CHO binding to human CD15/FUT4. Technetium (99mTc) fanolesomab is a mouse monoclonal antibody formerly used to aid in the diagnosis of appendicitis. It is labeled with a radioisotope, technetium-99m (99mTc).
Antibody Indication
Appendicitis (Radionuclide imaging)
Appendicitis (Radionuclide imaging)
