Anti-CD11a Efalizumab Antibody, a Fc Silent Biobetter (CAT#: FCS-056P) Datasheet

Human

Monoclonal

Humanized IgG1

Efalizumab

Unconjugated

Recombinant

PBS, pH 7.4

Funcs, In vivo assay

The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.

Product should be stored at -20°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.

CD11a

CD11A

CD11A

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity.

CD11A; LFA-1; ITGAL