Full Name
Fucosyltransferase 4
Background
The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]
Alternative Names
technetium (99mTc) fanolesomab;neutrospec;225239-31-6;FUT4;fucosyltransferase 4 (alpha (1, 3) fucosyltransferase, myeloid-specific);CD15, ELFT, FCT3A;alpha-(1, 3)-fucosyltransferase;ELAM ligand fucosyltransferase;FUC TIV;galactoside 3 L fucosyltransferase
Cellular Localization
Golgi apparatus
Involvement in Disease
Diseases associated with FUT4 include Hodgkin's Lymphoma, Mixed Cellularity and Hodgkin's Lymphoma, Lymphocytic-Histiocytic Predominance.
Related Pathways
Its related pathways are Glycosphingolipid biosynthesis - lacto and neolacto series and Metabolism.
Function
May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.
Post-translational modifications
1.Glycosylation at Asn216 and Asn315 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
technetium (99mTc) fanolesomab
Description
Recombinant mouse monoclonal antibody expressed in CHO binding to human CD15/FUT4. Technetium (99mTc) fanolesomab is a mouse monoclonal antibody formerly used to aid in the diagnosis of appendicitis. It is labeled with a radioisotope, technetium-99m (99mTc).
Indication
Appendicitis (Radionuclide imaging)
