Non-fucosylated Anti-Human BLyS (Belimumab) Therapeutic Antibody (CAT#: BioBet-035ZP) Datasheet

TNFSF13B

TNFSF13B

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

TNFSF13B, THANK, Tumor Necrosis Factor (Ligand) Superfamily, Member 20, BAFF, TNF- And APOL-Related Leukocyte Expressed Ligand 1, B-Cell-Activating Factor, Tumor Necrosis Factor Ligand Superfamily Member 13B, BLYS

Plasma membrane, Extracellular region or secreted

Diseases associated with TNFSF13B include Sialadenitis and Sjogren Syndrome.

Its related pathways are NF-KappaB Family Pathway and PEDF Induced Signaling.

1.Cytokines that bind to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same two receptors. Together, they form a 2-ligand-2 receptor pathway, which participates in the stimulation of B cell and T cell functions and the regulation of humoral immunity. The third type of b-cell specific BAFFR-receptor (BAFFR/BR3) promotes the survival of mature b-cells and the response of b-cells. 2.Isoform 2 seems to inhibit the secretion and biological activity of Isoform 1. 3.[Isoform 3]: As a transcription factor of its parent gene, it is related to the nf-kpa-b p50 subunit, at least in autoimmune and proliferative b-cell diseases. The presence of Delta4BAFF is essential for the release of soluble BAFF from monocytes stimulated by IFNG/ifn-γ and the survival of b cells. It can directly or indirectly regulate the differential expression of a large number of genes involved in innate immune response and regulating cell apoptosis.

Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody

The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. N-glycosylated.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1

Belimumab

Human

Human

Belimumab previously known as LymphoStat-B. It is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS).

Active autoantibody-positive Systemic lupus erythematosus

Actemra, RoActemra, Atlizumab

Interleukin 6 (IL-6) is a cytokine that plays an important role not only in the immune response, but also in hematopoietic and central nervous systems. IL-6 is involved in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma, and prostate cancer.
Tocilizumab is a recombinant, humanized anti-human interleukin 6 (IL-6) receptor monoclonal antibody that specifically binds soluble and membrane-bound IL-6 receptors (sIL-6R and mIL-6R), thus inhibiting IL-6-mediated signaling through these receptors.

Active autoantibody-positive Systemic lupus erythematosus