Description
Anti-BLyS Antibody, Highly Galactosylated (BioBet-GA-035ZP) is a human IgG1 antibody against BLyS which contains with a high level of galactosylation.
Antibody Indication
Systemic lupus erythematosus
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced BLyS antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TNFSF13B
Full Name
TNFSF13B
Background
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Alternative Names
TNFSF13B, THANK, Tumor Necrosis Factor (Ligand) Superfamily, Member 20, BAFF, TNF- And APOL-Related Leukocyte Expressed Ligand 1, B-Cell-Activating Factor, Tumor Necrosis Factor Ligand Superfamily Member 13B, BLYS
Gene ID
10673
UniProt ID
Q9Y275
Cellular Localization
Plasma membrane, Extracellular region or secreted
Genecards
11929
Involvement in Disease
Its related pathways are NF-KappaB Family Pathway and PEDF Induced Signaling.
Related Pathways
1.Cytokines that bind to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same two receptors. Together, they form a 2-ligand-2 receptor pathway, which participates in the stimulation of B cell and T cell functions and the regulation of humoral immunity. The third type of b-cell specific BAFFR-receptor (BAFFR/BR3) promotes the survival of mature b-cells and the response of b-cells. 2.Isoform 2 seems to inhibit the secretion and biological activity of Isoform 1. 3.[Isoform 3]: As a transcription factor of its parent gene, it is related to the nf-kpa-b p50 subunit, at least in autoimmune and proliferative b-cell diseases. The presence of Delta4BAFF is essential for the release of soluble BAFF from monocytes stimulated by IFNG/ifn-γ and the survival of b cells. It can directly or indirectly regulate the differential expression of a large number of genes involved in innate immune response and regulating cell apoptosis.
Function
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
Field of research
The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. N-glycosylated.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-GA-035ZP
Description
Belimumab previously known as LymphoStat-B. It is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS).
Antibody Indication
Active autoantibody-positive Systemic lupus erythematosus
Active autoantibody-positive Systemic lupus erythematosus
