Non-Fucosylated Anti-Human B7-H3 (MGA271) Therapeutic Antibody (CAT#: BioBet-654ZP) Datasheet

CD276

CD276 molecule

The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

CD276; CD276 molecule; B7H3; B7-H3; B7RP-2; 4Ig-B7-H

Membrane

Diseases associated with CD276 include Mycoplasma Pneumoniae Pneumonia and Brain Glioma.

Its related pathways are Cell adhesion molecules (CAMs) and NF-kappaB Signaling.

It may be involved in the regulation of T cell-mediated immune response. It may protect tumor cells by inhibiting natural killer-mediated cell lysis, and can be used as a marker for neuroblastoma cell detection. May participate in the development of acute and chronic transplant rejection and regulate the activity of lymphocytes on the mucosal surface. It also played a key role in providing a suitable immune environment for the placenta and fetus throughout the pregnancy. isoform 1 and isoform 2 seem to be redundant in their ability to regulate CD4 t cell responses. Isoform 2 has been shown to enhance the induction of cytotoxic T-cells and selectively stimulate the presence of T-cell receptor signals for interferon gamma production.

Cancer antibody; Developmental Biology antibody; Immune System antibody

1.Glycosylation at Asn91, Asn104, Asn189, Asn407, Asn215, Asn433, and Asn322 2.Modification sites at PhosphoSitePlus 3.Glycosylation from GlyConnect

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

MGA271

Humanized

Human

MGA271 is a first-in-class, humanized IgG1κ monoclonal antibody that recognizes human B7-H3, a novel member of the B7 family of immune regulators. MGA271 has been Fc-engineered to further augment its tumor killing activity.

Solid Tumors

Solid Tumors