IT Type
Antibody-based IT
Description
A novel SAS1B-targeting immunotoxin is assembled the Fab fragment of anti-SAS1B monoclonal antibody with saporin.
Indication
Breast cancer, ovarian carcinoma, head and neck cancers, uterine cancer
Classification
Immuntoxin; biobetter
Construction
Fab-Saporin
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
SAS1B
Full Name
SAS1B
Alternative Names
SAS1B
Antibody Clone
D-8
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
Fab
Antibody Indication
Breast cancer, ovarian carcinoma, head and neck cancers, uterine cancer
Toxic Moiety
Saporin
Organism
Saponaria officinalis
Family
Plant toxin
Toxic MOA
Saporin, a plant toxin derived from Saponaria officinalis, disrupts protein synthesis by inactivating the 60S portion of the ribosomal complex.
The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.
Breast cancer, ovarian carcinoma, head and neck cancers, uterine cancer
