Anti-VEGF A Antibody, Non-Fucosylated (BioBet-1423ZP) (CAT#: BioBet-1423ZP) Datasheet

VEGFA

vascular endothelial growth factor A

This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

Extracellular region or secreted

Diseases associated with VEGFA include Microvascular Complications Of Diabetes 1 and Poems Syndrome.

Its related pathways are HIF1Alpha Pathway and Cell adhesion_Plasmin signaling.

The activity of growth factors in angiogenesis, angiogenesis and endothelial cell growth. Induce endothelial cell proliferation, promote cell migration, inhibit cell apoptosis, and induce vascular permeability. It binds to FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparin sulfate and heparin. NRP1/Neuropilin-1 binds to subtypes of VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR, but does not activate downstream signaling pathways, does not activate angiogenesis, and inhibit tumor growth. Binding to the NRP1 receptor initiates the signal pathways required for motor neuron axon guidance and cell body migration, including the migration of facial motor neurons from rhombomere 4 to the tail of rhombomere 6 during embryonic development (similar).

Cancer antibody; Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody

1.Glycosylation at Asn101 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG2κ

BioBet-1423ZP

Human

Human

PF-00547659 is an anti-human MAdCAM monoclonal antibody used for the treatment of cancer.

Cancer

Cancer