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Creative Biolabs - ADCC+ Antibody

Anti-Troponin I Antibody, Non-Fucosylated (19C7) (CAT#: BioBet-1407ZP) Datasheet

Target
Troponin I
Isotype
IgG
Description
Anti-Troponin I Antibody, Non-Fucosylated (BioBet-1407ZP) is a humanized monoclonal IgG antibody against Troponin I. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Myocardial Infarction; Acute Coronary Syndrome
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Troponin I antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
Troponin I
Full Name
Troponin I
Background
Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it, myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character.
Alternative Names
Troponin I
Cellular Localization
Cytosol, Cytoskeleton
Involvement in Disease
Diseases associated with TNNT1 include Nemaline Myopathy 5 and Nemaline Myopathy.
Related Pathways
Its related pathways are Cardiac conduction and Striated Muscle Contraction.
Function
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Field of research
Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Signaling Transduction antibody
Post-translational modifications
Phosphorylated at Ser-42 and Ser-44 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity). Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
19C7
Host
Humanized
Species Reactivity
Human
Description
The antibody to troponin I may be used to detect Troponin I in a patient and may also be used in the diagnosis of, for example, a myocardial infarction or acute coronary syndrome.
Antibody Indication
Myocardial Infarction; Acute Coronary Syndrome

Myocardial Infarction; Acute Coronary Syndrome

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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