Non-Fucosylated Anti-Human TNF receptor 1 (GSK 1995057) Therapeutic Antibody (CAT#: BioBet-1382ZP) Datasheet

TNFRSF1A

tumor necrosis factor receptor superfamily, member 1A

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A; FPF; MS5; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55; TNFR1-d2; tumor necrosis factor receptor superfamily member 1A; TNF-R1; TNF-RI; TNFR-I; tumor necrosis factor-alpha receptor; tumor necrosis factor receptor type 1; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1A isoform beta

Plasma membrane, Extracellular region or secreted, Golgi apparatus

Diseases associated with TNFRSF1A include Periodic Fever, Familial, Autosomal Dominant and Multiple Sclerosis 5.

Its related pathways are Apoptosis Modulation and Signaling and Signal transduction_JNK pathway.

The receptor TNFSF2/tnf-and the homotrimer TNFSF1/lymphtoxin-. The adaptor molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signal complex (DISC) performs proteolytic activation of caspase-8, which in turn initiates a cascade of caspase (aspartate-specific cysteine protease) and mediates apoptosis. Helps induce non-cell-killing TNF effects, including antiviral status and activation of acid sphingomyelinase

Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody; Signaling Transduction antibody

The soluble form is produced from the membrane form by proteolytic processing.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

GSK 1995057

Human

Human

GSK1995057 is a fully human, single domain antibody directed against the TNFR1 receptor, used for acute lung injury.

Acute Lung Injury

Acute Lung Injury