Anti-Stromal Cell-derived Factor-1 alpha Antibody, Non-Fucosylated (BioBet-756ZP) (CAT#: BioBet-756ZP) Datasheet

CXCL12

chemokine (C-X-C motif) ligand 12

This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

CXCL12; chemokine (C-X-C motif) ligand 12; IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12; stromal cell-derived factor 1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor

Extracellular region or secreted

Diseases associated with CXCL12 include Human Immunodeficiency Virus Type 1 and Whim Syndrome.

Its related pathways are Signaling by GPCR and NF-KappaB Family Pathway.

Chemotactic agents are active on T lymphocytes and monocytes, but have no effect on neutrophils. Activating the C-X-C chemokine receptor CXCR4 induces a rapid and short-term increase in intracellular calcium levels and chemotaxis. The chemotactic activity of sdf-1-(3-72) and sdf-1-(3-67) decreased. Binding to cell surface proteoglycans appears to inhibit the formation of sdf-1-(3-67), thereby maintaining activity at local sites. It also binds to the atypical chemokine receptor ACKR3, which activates the -arrestin pathway and acts as a scavenger receptor for SDF-1. Binding to the variable structure site (2 sites) of integrin, activate the integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a cxcr4-independent manner. Through LYN kinase, it plays a positive role in regulating monocyte migration and negatively regulating monocyte adhesion. Stimulates the migration of monocytes and T lymphocytes through their receptors CXCR4 and ACKR3, and reduces the adhesion of monocytes to the surface coated with the -2 integrin ligand ICAM-1. The SDF1A/CXCR4 signal axis inhibits monocyte adhesion to ICAM-1 mediated by integrin-2 integrin LFA-1 through LYN kinase. Inhibit cxcr4-mediated t cell line adaptation to HIV-1 infection. Play a protective role after myocardial infarction. Induce the down-regulation and internalization of ACKR3 expressed by different cells. There are several key functions during embryonic development; it is necessary for b-cell lymphogenesis, bone marrow production and ventricular septum formation. In the presence of IL7, it promotes the proliferation of bone marrow-derived b cell progenitor cells and the growth of stromal cell-dependent pre-b cells (through similarity).

Cell Biology and Cellular Response antibody; Immune System antibody; Microbiology and Infectious Disease antibody

Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-756ZP

Human

Human

The human monoclonal antibody that specifically bind to SDF-1 with high affinity can be used for detecting SDF-1, as well as treating various B cell malignancies, including breast cancer, multiple myeloma and non-Hodgkin's lymphoma, and autoimmune disorders.

Autoimmune Diseases; Biliary Cirrhosis, Primary

Autoimmune Diseases; Biliary Cirrhosis, Primary