Non-Fucosylated Anti-Human Semaphorin 4A (161-51) Therapeutic Antibody (CAT#: BioBet-1272ZP) Datasheet

SEMA4A

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

SEMA4A; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; RP35; SEMB; SEMAB; CORD10; semaphorin-4A; sema B; semaphorin-B

Plasma membrane

Diseases associated with SEMA4A include Retinitis Pigmentosa 35 and Cone-Rod Dystrophy 10.

Its related pathways are Axon guidance and Developmental Biology.

PLXNB1, PLXNB2, PLXNB3 and PLXND1 are cell surface receptors that play an important role in cell-cell signaling (similarity). Regulates the development of glutamatergic and GABAergic synapses (through similarity). Promote the development of inhibitory synapses in a plxnb1-dependent manner, and promote the development of excitatory synapses (through similarity) in a plxnb2-dependent manner. Activate antigen-specific t cells to promote Th1 t helper cell differentiation, thereby promoting adaptive immunity (through similarity). Promote the phosphorylation of TIMD2 (through similarity). Inhibit angiogenesis (through similarity). Promote axonal growth cone collapse (similar). By providing a local signal to specify the area that the growing axon cannot reach (through similarity), the axon expansion is inhibited.

1.Glycosylation at Asn120, Asn135, Asn496, and Asn607 2.Modification sites at PhosphoSitePlus 3.Ubiquitination at Lys219 and Lys535

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

161-51

Humanized

Human

The anti-human sema4A antibody are useful in treating autoimmune diseases, cancers and other disease. Anti-human sema4A antibody can inhibit T cell proliferation and Th2 differentiation induced by IL-4, anti-CD3, anti-CD28 and recombinant sema4A.

Autoimmune Disease; Cancer

Autoimmune Disease; Cancer