Description
Anti-Progranulin Antibody, Non-Fucosylated (BioBet-955ZP) is a human monoclonal IgG antibody against Progranulin. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Progranulin antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
GRN
Full Name
granulin
Background
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Alternative Names
GRN; granulin; GEP; GP88; PEPI; PGRN; CLN11; PCDGF; granulins; acrogranin; progranulin; proepithelin; granulin-epithelin; PC cell-derived growth factor
Gene ID
2896
UniProt ID
Q9UK05
Cellular Localization
Extracellular region or secreted, Lysosome
Involvement in Disease
Diseases associated with GRN include Ceroid Lipofuscinosis, Neuronal, 11 and Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related.
Related Pathways
Its related pathways are Innate Immune System and Integrated Breast Cancer Pathway.
Function
Secreted protein, which is a key regulator of lysosomal function and a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein transport to lysosomes and also regulates lysosomal enzyme activity. It also promotes the acidification of lysosomes, causing CTSB to degrade mature CTSD. In addition, as a wound-related growth factor, it directly acts on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (similar). By blocking tnf-mediated neutrophil activation, preventing the release of oxidants and proteases, and promoting epithelial cell proliferation. In addition, it regulates inflammation in neurons by protecting neuron survival, axon growth and neuron integrity.
Field of research
Cancer antibody; Immune System antibody; Neuroscience antibody
Post-translational modifications
Granulins are disulfide bridged.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
AG1
Description
This is a neutralizing anti-GP88 antibody, inhibits GP88 biological effect (proliferation and migration) in a dose-dependent fashion in vitro, used for treating breast cancer.
Antibody Indication
Cancer
