Non-Fucosylated Anti-Human PDGFRA (24A1) Therapeutic Antibody (CAT#: BioBet-1496ZP) Datasheet

PDGFRA

Platelet-derived growth factor receptor A

PDGFRA

Golgi apparatus, Plasma membrane

Diseases associated with PDGFRA include Gist-Plus Syndrome and Hypereosinophilic Syndrome, Idiopathic.

Its related pathways are RET signaling and Phospholipase D signaling pathway.

Tyrosine protein kinase, as the cell surface receptor of PDGFA, PDGFB and PDGFC, plays an important role in regulating embryonic development, cell proliferation, survival and chemotaxis. According to specific conditions, promote or inhibit cell proliferation and cell migration. It plays an important role in the differentiation of bone marrow mesenchymal stem cells. Necessary for normal bone development and cephalic closure during embryonic development. It is necessary for the normal development of the gastrointestinal mucosa, the recruitment of mesenchymal cells and the normal development of intestinal villi. It plays a role in cell migration and chemotaxis in wound healing. Play a role in platelet activation, platelet granule agonist secretion and thromboxane-induced platelet aggregation. The combination of its homoligand-homodimer PDGFA, homodimer PDGFB, heterodimer or homodimer PDGFC formed by PDGFA and PDGFB-leads to the activation of multiple signal cascades; the response depends on the binding The nature of the ligand is regulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylate PIK3R1, PLCG1 and PTPN11. Activation of PLCG1 leads to the production of cell signaling molecules diglyceride and inositol 1,4,5-trisphosphate, mobilization of cytosolic calcium (2+) and activation of protein kinase c to phosphorylate PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, which mediates the activation of the AKT1 signaling pathway. Mediates the activation of HRAS and MAPK1/ERK2 and/or MAPK3/ERK1. Promote the activation of STAT family members STAT1, STAT3, STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatase (dephosphorylation of the receptor and its downstream effectors) and rapid internalization of activated receptors.

Cancer antibody; Cell Biology and Cellular Response antibody; Signaling Transduction antibody

N-glycosylated. Ubiquitinated, leading to its degradation. Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-731 and Tyr-742 is important for interaction with PIK3R1. Phosphorylation at Tyr-720 and Tyr-754 is important for interaction with PTPN11. Phosphorylation at Tyr-762 is important for interaction with CRK. Phosphorylation at Tyr-572 and Tyr-574 is important for interaction with SRC and SRC family members. Phosphorylation at Tyr-988 and Tyr-1018 is important for interaction with PLCG1.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

24A1

Humanized

Human

The antibody recognizes specifically human PDGF receptor alpha. It can be used for colon tumors.

Colon Tumors

Colon Tumors