Anti-Laminin-5 alpha 3 Antibody, Non-Fucosylated (BioBet-1163ZP) (CAT#: BioBet-1163ZP) Datasheet

LAMA3

laminin, alpha 3

The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants.

LAMA3; laminin, alpha 3; E170; LOCS; BM600; LAMNA; laminin subunit alpha-3; laminin A3; BM600 150kD subunit; nicein 150kD subunit; nicein subunit alpha; LAM3, alpha-3 subunit; kalinin 165kD subunit; kalinin subunit alpha; laminin-5 alpha 3 chain; laminin-5 subunit alpha; laminin-6 subunit alpha; laminin-7 subunit alpha; epiligrin 170 kda subunit; epiligrin alpha 3 subunit; laminin 5, alpha-3 subunit; laminin, alpha 3 (nicein (150kD), kalinin (165kD), BM600 (150kD), epilegrin)

Extracellular region or secreted

Diseases associated with LAMA3 include Laryngoonychocutaneous Syndrome and Epidermolysis Bullosa, Junctional, Herlitz Type.

Its related pathways are Integrin Pathway and Signaling by GPCR.

Laminin binds to cells through high affinity receptors, which is believed to mediate cell attachment, migration and organization during embryonic development by interacting with other extracellular matrix components. Lamin5 is believed to be involved in (1) adhesion of integrin-3 / - 1 and integrin-6 / - 4 in cell adhesion, (2) signal transduction of phosphorylation of pp125 FAK and p80 tyrosine, and (3) differentiation of keratinocytes.

1.Glycosylation at Asn142, Asn242, Asn2365, Asn2502, Asn2584, Asn2751, Ser2975, and Asn3097 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1163ZP

Humanized

Human

This is a monoclonal antibody binding to Laminin3 related to the medical application, in particular for treating cancer.

Cancer

Cancer