Full Name
adhesion molecule, interacts with CXADR antigen 1
Alternative Names
AMICA1; adhesion molecule, interacts with CXADR antigen 1; JAML; AMICA; Gm638; CREA7-1; CREA7-4; junctional adhesion molecule-like; adhesion molecule AMICA; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; adhesion molecule interacting with CXADR antigen 1
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with JAML include Febrile Seizures, Familial, 5.
Related Pathways
Its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+.
Function
A transmembrane protein of the plasma membrane of leukocytes, which controls the migration and activation of leukocytes by interacting with CXADR, which is a plasma membrane receptor found on neighboring epithelial cells and endothelial cells. The interaction between these two receptors mediates the activation of gamma-delta T cells, which are a subset of T cells in epithelial cells, and are involved in tissue homeostasis and repair. Through epithelial cell cxadr binding, JAML induces downstream cell signaling events in delta T cells through pi3-kinase and MAP kinase. It leads to the proliferation of T cells and the production of cytokines and growth factors, which in turn stimulates epithelial tissue repair. It also controls the migration of leukocytes in epithelial and endothelial tissues through adhesion interaction with epithelial and endothelial CXADR.
Post-translational modifications
1.Glycosylation at Asn76 and Asn231 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description
The antibody that specifically bind JAM-like protein (JAML) are useful in a variety of settings such as diagnostic screening, bioassays, and therapeutic intervention for diseases or conditions that are associated with JAML and/or CAR such as inflammation, cancer, scarring, wound healing, respiratory diseases, and other disorders related to epithelial inflammation.
