Non-Fucosylated Anti-Human Immunoglobulin Germline VH1-69 (huG6.2) Therapeutic Antibody (CAT#: BioBet-1029ZP) Datasheet

Ig VH1-69

Immunoglobulin germline VH1-69

The leukemic B cells of patients with chronic lymphocytic leukemia (CLL) express a restricted Ig heavy chain variable region gene (VH gene) repertoire. Certain alleles of the IgVH1-69 locus are favored in CLL. The average length of the heavy chain third complementarity-determining regions (CDR3) of VH1-69-expressing leukemia cells is significantly longer than that of normal adult B cells that also express Ig encoded by VH1-69 genes.

Ig VH1-69; Immunoglobulin germline VH1-69; 51p1

Plasma membrane, Extracellular region or secreted

The V region of the variable region of the immunoglobulin heavy chain involved in antigen recognition. Immunoglobulins, also called antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition stage of humoral immunity, membrane-bound immunoglobulin acts as a receptor and binds to a specific antigen to trigger the expansion of B lymphocyte clones and differentiate into plasma cells that secrete immunoglobulin. The secreted immunoglobulin mediates the fluid immune response phase, leading to the elimination of bound antigens. The antigen binding site is composed of a variable domain of a heavy chain and a variable domain of a light chain related to it. Therefore, each immunoglobulin has two antigen binding sites that have significant affinity for a specific antigen. The variable domains are assembled through a process called V-(D)-j rearrangement, followed by somatic hypermutation, which allows the affinity maturation of specific antigens after exposure to antigen and selection.

1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

huG6.2

Humanized

Human

This is a humanized monoclonal antibody that binds to the human immunoglobulin heavy chain variable region gerrnline gene VHI -69. The antibody is derived from Mab G6 and recognizes the same epitope. Moreover, the antibody is used in combination with vaccines to augment an immune response to microbial infection.

Microbial Infection

Microbial Infection