Anti-ILT7 Antibody, Non-Fucosylated (BioBet-1179ZP) (CAT#: BioBet-1179ZP) Datasheet

LILRA4

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4

This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4.

LILRA4; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4; ILT7; CD85g; leukocyte immunoglobulin-like receptor subfamily A member 4; immunoglobulin-like transcript 7; CD85 antigen-like family member G; leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 4

Plasma membrane

Diseases associated with LILRA4 include Pitt-Hopkins Syndrome.

Its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

The functional co-receptor limits the innate immune response to viral infection; the signal occurs through FCER1G. Down-regulating the production of IFNA1, IFNA2, IFNA4, IFNB1 and tumor necrosis factor plasma dendritic cells exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotide, the indicator function as a negative regulation of TLR7 and TLR9 recognition signal cascade. By interacting with BST2 on HIV-1 infected cells, it down-regulates the production of interferon. It cascades with FCER1G activation signal, which leads to phosphorylation of Src family and Syk kinase, which triggers the mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells.

1.Glycosylation at Asn138, Asn239, Asn279, and Asn300 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1179ZP

Humanized

Human

Anti-ILT7 antibody binds to plasmacytoid dendritic cells (pDCs), a subset of dendritic cells (DCs). pDCs is known as a major source of IFNα; overproduction of IFNα is considered to be one of the major causes of autoimmune diseases. Anti-ILT7 antibody specifically recognizes and kills pDCs to suppress the IFNα supply, which leads to the improvement of autoimmune disease symptoms.

Autoimmune Diseases

Autoimmune Diseases